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KMID : 0359920100290060776
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Korean Journal of Nephrology
2010 Volume.29 No. 6 p.776 ~ p.781
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MPO-ANCA Associated Rapidly Progressive Glomerulonephritis in A Patient with Mixed Connective Tissue Disease
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Hong Hyun-Seok
Park Ji-Hoon
Lee Ju-Hyun
Yi Joo-Hark
Han Sang-Woong
Park Moon-Hyang
Kim Ho-Jung
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Abstract
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Mixed connective tissue disease (MCTD) has the clinical feature of other collagen vascular diseases. According to several reports recently published, MCTD sometimes involved kidney as benign course. ANCA associated glomerulonephritis occurred in systemic autoimmune disease such as systemic sclerosis or rheumatoid arthritis, not in MCTD. In this case, as we experienced that MPO-ANCA associated glomerulonephritis arose and proceeded to rapid progressive glomerulonephritis (RPGN) in women with MCTD, we report it with review of reference. A 60-year-old woman was admitted with uremia and joint pain. In physical finding and serum test, she was diagnosed with MCTD according to Khan`s criteria. Also MPO antibody and ANCA were noted in specific immunological test and the histologic findings showed crescentic glomerulonephritis. So we diagnosed RPGN induced by MPO-ANCA associated glomerulonephritis. She was treated with immunosuppressive treatment and uremia was improved. RPGN induced by MPO-ANCA associated glomerulonephritis should be ruled out by prompt renal biopsy and require proper treatment.
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KEYWORD
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ANCA, Glomerulonephritis, Mixed connective tissue disease
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